Macrocyclic drugs are among leading current therapeutics for hepatitis C (Figure 1a) and other previously debilitating viral infections, and are emerging candidates for oncology applications.1 Methods for their production are of keen interest, as are methods that accelerate the identification of highly promising drug candidates. Olefin metathesis holds major promise in both contexts, owing to the unequalled synthetic versatility of ring-closing metathesis (RCM) as a catalytic methodology. The surprising mechanistic role of 'competing' oligomerization reactions2,3 for conformationally unconstrained dienes will be described (Figure 1b). New opportunities for the assembly of DNA-encoded libraries via metathesis catalysts designed for water- and DNA-compatibility4 will be discussed.
Secretária: Simone Regina Luiz Gomes
Email: pgquimic@qui.ufmg.br
Telefone: 31 3409 5732
PÓS-GRADUAÇÃO EM QUÍMICA – UNIVERSIDADE FEDERAL DE MINAS GERAIS
Av. Antônio Carlos, 6627 – 31270-901 – Belo Horizonte MG Brasil